What the Company Actually Does

Cell Culture Technologies' core business is centered on pioneering the development and manufacturing of highly specific, fully synthetic cell culture media and related proprietary technologies for the biopharmaceutical and academic research sectors. Their expertise lies in creating chemically defined, protein- and peptide-free minimal culture media, which is a critical advancement for bioprocessing and drug development.

The company's key strengths and proprietary technology encompass several areas of know-how: * Minimal Culture Environments: Development of expertise for the cultivation and cryopreservation of various human and animal cell lines in minimal culture media. * Bioprocess Development: Specialized knowledge in bioprocess development using animal cells cultivated in chemically defined media, entirely free of proteins and peptides. * Large-Scale Manufacturing: Know-how regarding the development and large-scale manufacturing of fully synthetic cell culture media formulations.

Cell Culture Technologies provides expertise and tailored solutions through long-standing collaborations with a strong client base, ranging from academic institutions to small biotechs and global Big Pharma companies. Their efforts are focused on the production of cells and biotherapeutics in these advanced, fully synthetic culture environments. The European Collection of Cell Cultures (ECACC) has distributed several of their serum-free adapted mammalian cell lines since 2003, highlighting the industry acceptance of their minimal media. Furthermore, the company offers its proprietary CHO cell line, ChoMaster®EPO, which is recognized as a promising host cell line for next-generation bioprocesses, including the manufacturing of biosimilars.

Products and Services

Cell Culture Technologies offers a portfolio of branded and custom products, along with specialized technology transfer programs, to support the biopharma industry and academic research.

Products: Minimal Culture Media and Solutions

The company's media formulations are characterized by several critical features: they exclusively contain small molecules with CAS- and EINECS registry numbers, and they are entirely free of proteins, peptides, complex additives (such as hydrolysates and yeast extracts), and animal-derived components. These products are used for both routine maintenance and long-term cryopreservation of cells.

Key Branded Products and Applications:

• ChoMaster®Media: Designed for the routine maintenance and long-term preservation of Chinese Hamster Ovary (CHO) cells used in the production of recombinant proteins in protein- and peptide-free minimal culture media.
• ChoMaster®EPO: Features the world's first open-source CHO cell line that secretes recombinant human erythropoietin (rh-EPO) in a chemically defined, protein- and peptide-free minimal culture medium.
• TurboDoma: Specifically for the routine maintenance and long-term preservation of hybridomas and myeloma cell lines used for monoclonal antibody production.
• Hektor???: Used for the cultivation of human embryonic kidney (HEK 293) cells and monkey kidney (Vero) cells for producing recombinant proteins and viral particles.
• InVitrus???: Supports the routine maintenance and long-term preservation of mammalian kidney cell lines and human T-lymphoma cell lines for viral particle production.
• SteMaxOne???: Tailored for the in vitro routine maintenance of human mesenchymal stem cells and stem cell lines in protein- and peptide-free minimal culture media, also showing efficacy for human stem cell research.
• SpodOmics: Dedicated to the routine maintenance and long-term cryopreservation of insect cell lines, such as Spodoptera frugiperda (Sf9).
• PlantCells: Supports the routine maintenance of plant cells for various bioprocess applications.
• InVitroNutrition: A platform for the customization and optimization of chemically defined, human plasma-like culture media and solutions for primary human cells.
• StarterKits???: Minimal culture media and methods for the routine maintenance and cryopreservation of serum-free authenticated and certified mammalian cell lines.
• Custom-made Products: The company develops and prepares a large number of customized media formulations and solutions, including specialized media for the growth of primary neurons and other unique cell types, upon request for academic and industrial application.

Services: Technology Transfer Programs and Expertise

Cell Culture Technologies offers its specialized know-how through four distinct technology transfer models. These programs are designed to assist clients in generating a range of products within fully synthetic culture environments.

Core Service Offerings: * Technology Transfer: Programs focused on enabling the client to generate recombinant glycoproteins, monoclonal antibodies, viral particles, and various cells in fully synthetic culture systems, allowing for the development of product pipelines. * Bioprocess Development Support: Assisting biopharma companies with developing product pipelines, for instance, by cultivating CHO cells and hybridomas in the company's minimal media. * Customization and Optimization: Providing services for the development and application of highly specific cell culture media and methods tailored to the client's unique needs. * Technical Support: Offering full implementation of their know-how and extensive technical support via a team of highly qualified professionals.