Antibody Solutions: A Contract Research Organization for Antibody Discovery
Antibody Solutions is a privately held American contract research organization (CRO) with a focus on antibody discovery and development, headquartered in Santa Clara, California. Founded in 1995, the company provides a comprehensive suite of research and production services to biopharmaceutical and diagnostic companies, as well as academic and institutional laboratories worldwide. The company's core mission is to empower clients in their research and development efforts by delivering high-quality, fit-for-purpose antibodies designed for therapeutics, diagnostics, and critical reagents. Since its inception, Antibody Solutions has aimed to fill a gap in the market by being one of the first independent companies to focus on custom antibody discovery, and over 25 years of operation, its laboratory has selected more than 50,000 positive antibody clones.
The company operates on a fee-for-service model, which allows clients to retain their intellectual property (IP). They collaborate with researchers globally, including with nine of the top ten global pharmaceutical companies and researchers from the top five hundred in pharmas and biotechs.
Core Activities and Discovery Platform
Antibody Solutions' primary activity is serving as a trusted collaborator for thousands of discovery projects, leveraging a combination of deep scientific expertise and a robust, proven process. Their approach is centered around their proprietary Cellestive discovery platform and a diverse range of technology platforms. This platform and its related services enable the company to develop antibodies using various approaches, including leveraging partnerships with providers of human antibody transgenic animal platforms, such as OmniAb, Trianni, and Alloy Therapeutics. The company's scientific focus is broad, spanning therapeutic antibody discovery, critical reagent antibody development, alternative antibody modalities, and reagents for diagnostic assays.
A key area of innovation for Antibody Solutions has been the adoption of advanced technologies. For instance, in 2000, they were the first CRO to produce antibodies in CELLine flasks, pioneering the use of bioreactors in antibody research, and in 2006, they became the first company to offer high-throughput screening of antibodies to cell-surface antigens utilizing a custom-built, automated flow cytometry platform.
Products and Services Offered
Antibody Solutions offers comprehensive antibody research and production services, which can be engaged for projects ranging from a few steps to complex, multi-orchestrated processes. These services are categorized to support the entire lifecycle of antibody development:
Antibody Discovery and Generation Services
Therapeutic Antibody DiscoveryCell-receptor Monoclonal Antibody DevelopmentCritical Reagent Antibody DiscoveryMonoclonal Antibody DiscoveryPolyclonal Antibody DiscoveryAntigen Design and SynthesisIn vivo Animal Study-Grade Antibodies DevelopmentAnti-Idiotype Antibody ProductionSingle Plasma B-Cell Services (part of the Cellestive Discovery Platform)
Monoclonal and Polyclonal Antibody Manufacture (e.g., production, purification, conjugation)
Bioreactor TechnologyBioconjugationPeptide SynthesisCell Bank Storage
Assay and Analysis Services
Analytical Methods DevelopmentImmunoassay DevelopmentLigand-Binding Assay AnalysisDrug Potency Assay AnalysisImmunogenicity Assays for Reagents and ControlsPharmacokinetic Studies (including Anti-protein antibodies for PK studies)
Support for CAR-T ResearchAssay Development
The company also offers full technical and project management to guide clients through the entire discovery process. Antibody Solutions focuses on delivering validated, highly purified, and reproducible antibodies, leveraging its expertise in diverse technology platforms to achieve an efficient and successful discovery process for its clients.
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