Da-Ta Biotech Ltd. is a private biotechnology company and Contract Research Organization (CRO) headquartered in Israel. Founded and managed by Dr. Rinat Borenshtain-Koreh, the company functions as a boutique "beta site" and science incubator for the biomedical and pharmaceutical industries. It provides a comprehensive suite of laboratory services, allowing early-stage startups and established biotech firms to outsource critical research and development (R&D) processes ranging from proof-of-concept studies to advanced validation assays.
The company distinguishes itself by offering a flexible, "one-stop-shop" scientific environment. Instead of merely executing standard tests, Da-Ta Biotech positions itself as a strategic partner that can design custom protocols, establish cell banks, and guide projects through the complex pre-clinical phase. Its facilities are equipped to handle diverse biological systems, including bacteria, fungi, viruses, and mammalian tissue cultures, operating under strict Biosafety Level 1 (BSL-1) and Biosafety Level 2 (BSL-2) standards.
Laboratory Services and Scientific Capabilities
Da-Ta Biotech offers a multidisciplinary approach, integrating various fields of biology to support drug discovery and medical device testing.
Microbiology and Mycology
The company provides specialized bacteriology and mycology services where microorganisms serve both as subjects of study and tools for research.
* Antimicrobial Testing: Conducting assays to evaluate the efficacy of new drugs or formulations against specific bacterial or fungal strains.
* Bacteriophage Research: Investigating phages for therapeutic applications, including the establishment of phage banks and validating their use in antibacterial treatments.
* Fungal Studies: Research and development services focused on mycology, including culture and sensitivity testing.
Cell Biology and Tissue Culture
A core competency of Da-Ta Biotech is its extensive tissue culture capabilities, supporting oncology, dermatology, and immunology research.
* Cell Banking: The facility extracts, propagates, and maintains cell banks from various sources, including primary cells, cancer cell lines, and reference strains (e.g., ATCC).
* Cytotoxicity and Viability: Performing rigorous safety testing, including ISO 10993-5 compliant cytotoxicity assays for medical devices, as well as apoptosis and proliferation studies.
* Functional Assays: Designing complex cell-based models to measure cell migration, adhesion, differentiation, and wound healing rates.
* Transfection: Executing both transient and stable transfections to modify gene expression in target cells.
Molecular Biology and Virology
The company offers genomic services to advance genetic engineering and diagnostic development.
* Genetic Analysis: Utilizing PCR, Real-Time PCR, and Reverse Transcription to analyze gene expression and detect specific genetic markers.
* Cloning and Vector Engineering: Construction of primers, probes, and plasmids for protein expression or gene therapy applications.
* Virology Services: The lab is certified for BSL-2 viral research, working with Adenoviruses and Lentiviruses, which are critical vectors for modern pharmaceutical developments such as CAR-T therapies and cell immortalization.
Biochemistry and Protein Analysis
To understand the mechanism of action (MOA) of new drugs, Da-Ta Biotech provides detailed protein analysis services.
* Immunoassays: Utilizing ELISA and Western Blot techniques to detect and quantify specific proteins.
* Enzymatic Assays: Studying enzyme kinetics and protein-protein interactions to determine the druggability of compounds.
* Histology: ImmunoHistochemistry (IHC) services to visualize protein expression within tissue samples.
Specialized Pharmaceutical Development Platforms
Beyond standard biology, the company offers specialized platforms tailored for specific drug delivery and formulation challenges.
Franz Cell Diffusion Studies
Da-Ta Biotech operates a sophisticated Franz Cell system (Hamilton Vertical diffusion device) to support the development of topical treatments.
* Permeation Testing: This platform allows researchers to test how well creams, gels, ointments, or liquids penetrate biological membranes.
* Membrane Options: Studies can be conducted using artificial membranes, pig skin, or human skin to simulate real-world absorption.
Biocompatibility and Medical Device Testing
The company supports the medical device sector by ensuring products are biologically safe for human use.
* ISO Compliance: Testing is conducted according to international standards (specifically ISO 10993-5) to certify that materials do not cause toxic reactions in living tissue.
* Viscosity Testing: Measuring the internal resistance of fluid formulations to ensure they meet the physical specifications required for injection or topical application.
Consulting and Incubator Services
Da-Ta Biotech operates as a private incubator, providing not just equipment but also intellectual capital to its clients.
* R&D Consulting: The team assists in defining project milestones, characterizing scientific goals, and performing scientific due diligence for investors.
* Protocol Development: Helping researchers transition from academic concepts to robust, industrial-grade Standard Operating Procedures (SOPs).
* Beta Site Operations: acting as an external R&D arm for companies that prefer to outsource their laboratory infrastructure while maintaining close scientific oversight.
Please note: This information is generated by AI. For legal use, verify with company sources.
