Core Operations and Market Presence

Advion?s primary objective is to make high-end analytical science more accessible to researchers at the bench. By focusing on "compact" and "chemist-centric" designs, the company has removed the traditional requirement for dedicated mass spectrometry experts to run routine assays.

• Strategic Integration: The partnership between Advion and Interchim allows the company to provide a seamless workflow that connects synthesis, purification, and identification (the "Synthesis-Purification-Identification" cycle).
• Global Footprint: While manufacturing and R&D for mass spectrometry remain in Ithaca, the company maintains extensive support and sales offices in the United Kingdom, Japan, and France, serving the world's top 20 pharmaceutical companies and major government research agencies.

Products and Specialized Instrumentation

Advion?s product portfolio is categorized by its ability to provide rapid results with minimal sample preparation.

1. Mass Spectrometry (MS) Solutions

• expression? Compact Mass Spectrometer (CMS): The flagship single-quadrupole mass spectrometer designed specifically for the fume hood. It is small enough to fit in a laboratory bench space and can be integrated with various sampling techniques.
• SOLATION? ICP-MS: An Inductively Coupled Plasma Mass Spectrometer used for highly sensitive multi-elemental analysis, ideal for detecting trace elements in environmental, food, and clinical samples.
• TriVersa NanoMate?: A chip-based electrospray ionization (ESI) technology that combines the benefits of infusion, fraction collection, and direct surface analysis.

2. Purification and Chromatography Systems

• puriFlash? Flash and Prep-HPLC Systems: A range of purification instruments that utilize "Intelligent Flash" technology to automate the separation of chemical compounds.
• AVANT? (U)HPLC: A modular liquid chromatography system that can function as a standalone unit or integrate seamlessly with the expression? CMS.

3. Innovative Sampling Interfaces

One of Advion's most significant contributions to the field is the development of sampling techniques that eliminate traditional chromatography for simple compound ID: * Plate Express?: An automated system that reads thin-layer chromatography (TLC) plates and sends the sample directly to the mass spectrometer without scraping the plate. * Touch Express? Open Port Sampling Interface (OPSI): A tool for the direct analysis of solids, liquids, and fibers by simply touching them to a continuous solvent flow. * vAPCI (Volatile APCI): Designed for the direct analysis of volatile organic compounds (VOCs) in the gas phase (e.g., headspace analysis). * ASAP? (Atmospheric Solids Analysis Probe): A tool for the direct analysis of liquid and solid samples without the need for sample preparation.

Services and Research Support

In addition to hardware, Advion Interchim Scientific provides a suite of lifecycle services:

• Bioanalytical Services: Leveraging its history as a Contract Research Organization (CRO), the company offers expert consulting on method development and validation for pharmaceutical drug discovery.
• Mass Spec in the Classroom: A specialized educational package that includes a research-grade mass spectrometer and a pre-designed curriculum for university chemistry departments.
• Consumables and Media: Providing the widest range of high-capacity separation columns (over 30 different bonded phases) and sample preparation tools like SLE and SPE cartridges.

Targeted Applications

The company?s solutions are tailored to specific high-growth fields: * Natural Products & Cannabis: Providing integrated platforms for potency testing and safety screening (pesticides/heavy metals). * Proteomics & Large Molecules: Using extended mass range CMS units for the deconvolution of proteins, peptides, and oligonucleotides. * Reaction Monitoring: Enabling chemists to understand reaction progression in real-time at the bench, allowing them to determine the exact moment to quench a reaction.