Backed by investors such as Oxford Science Enterprises, the Stephenson Fund (Institution of Mechanical Engineers), and Parkwalk Advisors, ProXisense has secured significant competitive grants—including Innovate UK funding for advanced pharmaceutical process monitoring (Project SENSE)—and collaborative research initiatives like Analysis for Innovators (A4I).

Core Technologies and Sensing Principles

ProXisense bases its platform on advanced thermal, electromagnetic, and acoustic sensing principles designed to provide continuous data streams without sampling delays or invasive lab analysis.

1. Thermal Energy Exchange & Phase Sensing: The company's proprietary thermal pulse and dissipation technique enables non-destructive, real-time quantification of composition changes, solvent purity, and phase dynamics in liquids.
2. Extreme Environment Inductive & Capacitive Proximity Probing: ProXisense utilizes highly ruggedized probes capable of withstanding extreme temperatures, high vibrations, and high pressures to measure blade tip clearance, rotational speed, and metallic wear debris.
3. High-Frequency Transient Measurement: High-speed transducers capture microsecond-level fluctuations in pressure and temperature inside combustion chambers, fluid channels, and turbines.

Primary Product Offerings

1. LiquiSensor™ Technology Platform

The LiquiSensor™ is ProXisense's flagship liquid-phase sensing system designed for continuous Process Analytical Technology (PAT) and in-line fluid monitoring. * In-Line Solvent & Reaction Monitoring: Utilizes thermal energy exchange measurements to detect solvent composition, organic reaction progression, and blend uniformity in real time. * Water & Impurity Detection: Quantifies trace moisture, water contamination, or unwanted solute changes in organic liquids without requiring traditional off-line Karl Fischer titration. * Miniaturized Form Factors: Supported by Analysis for Innovators (A4I) research programs, miniaturized LiquiSensor variants are designed for integration into small-scale laboratory reactors, microfluidic systems, and compact bioprocessing rigs. * Plug-and-Play Hub Integration: Connects via a central ProXisense connector hub, streaming multi-channel raw sensor signals directly to proprietary data processing units.

2. High-Temperature and Harsh-Environment Probes

Engineered specifically for aerospace, defence, and heavy industrial machinery: * Air & Oil Condition Probes: Submersible and direct-line probes capable of continuously monitoring lubricant degradation, fuel contamination, and coolant quality under extreme temperature conditions. * Metal Debris Quantification Sensors: In-line inductive and magnetic probes that detect, count, and classify ferrous and non-ferrous wear particles suspended in engine oil or hydraulic fluid to provide early warnings of mechanical failure. * Blade Tip Clearance & Vibration Proximity Sensors: Non-contact proximity probes licensed and developed to measure the physical distance between rotating jet engine turbine blades and outer casings at high speeds and elevated temperatures. * High-Frequency Pressure & Temperature Transducers: Fast-response sensor packages that monitor high-velocity transient events inside gas turbines, turbofan engines, and fluid manifolds.

3. Medical Diagnostic Sensor Platforms

• Skin Lesion Screening Sensors: Ex vivo and in vivo diagnostic probes engineered to measure thermal or physical properties of tissue. Developed for clinical environments to assist general practitioners (GPs) and dermatologists with rapid, non-invasive screening of skin abnormalities.

Technical Services and Capabilities

In addition to standard sensor hardware, ProXisense provides specialized engineering services, customized hardware modifications, and software integration to suit custom enterprise applications.

1. Continuous Process Analytical Technology (PAT) Implementation

• Custom Process Integration: Designing and retrofitting LiquiSensor probes into existing batch or continuous pharmaceutical manufacturing lines.
• Process Optimization & Solvent Evaluation: Analyzing reaction thermal dynamics to assist chemical engineers in reducing solvent waste, reducing cycle times, and improving yield stability.

2. Aerospace & Industrial Condition Monitoring

• Custom Sensor Design & TRL Advancement: Tailoring mid-TRL (Technology Readiness Level) probes for aerospace OEMs and defence contractors seeking next-generation engine monitoring solutions.
• Predictive Maintenance Engineering: Integrating wear-debris and fluid-degradation sensors into predictive maintenance programs for high-value turbomachinery and industrial power units.

3. Data Acquisition & Analytics Software

• Real-Time Signal Processing: ProXisense provides proprietary analytical software that interfaces with its connector hubs, performing high-speed signal conditioning, noise filtering, and algorithmic analysis.
• API & Control System Integration: Exporting real-time sensor metrics directly to industrial Distributed Control Systems (DCS), Supervisory Control and Data Acquisition (SCADA) platforms, or laboratory information management systems (LIMS).

Target Industry Applications

| Sector | Application Focus | Key Technology / Product | | :--- | :--- | :--- | | Pharmaceuticals & Fine Chemicals | Real-time monitoring of organic reactions, solvent purity, and moisture levels in active pharmaceutical ingredient (API) synthesis. | LiquiSensor™ Platform / Project SENSE | | Aerospace & Defence | Continuous monitoring of jet engine lubricants, turbine blade tip clearance, and combustion chamber transients. | Ruggedized Proximity & Oil Condition Probes | | Industrial Machinery & Power | Early failure detection through oil degradation tracking, fluid contamination monitoring, and metallic debris analysis. | Metal Debris Probes & Coolant Sensors | | Healthcare & Diagnostics | Point-of-care, non-invasive tissue analysis and skin lesion classification during primary care clinical screenings. | Diagnostic Tissue Probes |