Gene Link, Inc. is a privately held biotechnology company founded in 1993 and situated in Hawthorne, New York, USA. Operating within the biotech and life sciences sector, the company has established itself as a leading supplier of premium custom oligonucleotides and genetic research tools for the global scientific community. Its core mission is to provide investigators with high-quality, specialized products and services that aid in fundamental and applied research, particularly relating to gene mapping, localization, and detection. Gene Link serves a diverse customer base, including universities, research institutes, pharmaceutical companies, and hospitals worldwide.
Core Business and Expertise
The central competency of Gene Link, Inc. lies in the synthesis and modification of nucleic acids, coupled with a focus on developing non-radioactive detection systems for genetic disorders. The company???s dedication to quality is highlighted by its use of advanced technology, such as Perseptive???s Expedite technology, to supply products, and a commitment to providing detailed quality control data, including physical data and gel pictures, with its custom oligonucleotides. They specialize in catering to demanding applications that require consistent, high-quality results.
Products and Services
Gene Link???s comprehensive offerings are categorized into custom services, specialized probes, genetic tools, and gene detection systems:
Custom Oligonucleotide and Nucleic Acid Synthesis
Custom Oligonucleotides: Gene Link is a principal supplier of custom oligonucleotides for a multitude of molecular biology applications, including Polymerase Chain Reaction (PCR), sequencing, cloning, ligation, and sequence mutagenesis.
Ultra-Modified Oligonucleotides: A particular strength is the synthesis of ultra-modified oligonucleotides. These can include various chemistries such as DNA, RNA, 2'-O-methyl, and chimeric oligos. They offer virtually all commercially available modifications, providing researchers with complex, customized molecules.
Long Oligo Synthesis: The company possesses unique capabilities in synthesizing exceptionally long oligonucleotides, routinely providing custom DNA oligonucleotides up to 250 monomers in length and RNA up to 125 monomers, often with a mix of complex modifications.
RNA Interference (RNAi): They supply key components for gene silencing research, including small interfering RNA (siRNA) and shRNA Explorer products.
Specialized Probes and Primers
The company manufactures a wide array of fluorescent and modified probes crucial for real-time PCR, genotyping, and other detection assays:
Fluorescent Molecular Probes: This product line includes cutting-edge tools such as Molecular Beacons, TaqMan Probes, and FRET (Fluorescence Resonance Energy Transfer) probes. Their proprietary synthesis and processing methods ensure superior quality for these highly sensitive applications.
Molecular Primers: They offer a variety of standard and specialty primers, including fluorophore-labeled primers, sequencing primers, and optimized primer sets (Genemer???) for the genotyping of various mutations.
Genetic Tools, Reagents, and Kits
Gene Link???s catalog includes a broad selection of reagents and ready-to-use kits for fundamental molecular biology research:
DNA and RNA Purification Systems: Sold under the Omni-Pure??? and Omni-Clean??? brands, these include purification kits for plasmid DNA, genomic DNA, viral DNA & RNA, microbial DNA, and plant DNA.
cDNA and mRNA Products: They offer Omni-cDNA??? (Pooled First Strand cDNA from various species and tissues) and Omni-RNA??? (Amplified Pooled Reference mRNA).
General Reagents: Stock primers, adaptors, linkers, random primers, and solutions for DNA & RNA precipitation and reconstitution are routinely supplied.
Molecular Weight Markers: The catalog includes both unlabeled DNA molecular weight markers (Omni-Marker???) and fluorescent dye-labeled markers (GScan???) for gel-based analysis.
Gene Detection Systems and Genotyping
A significant focus of Gene Link???s research and development is on creating non-radioactive gene detection systems for genetic disorders, positioning them as a leader in this niche.
Triple Repeat Disorder Genotyping: They have developed simple, safe, and reliable non-radioactive detection methods for genotyping human genetic disorders caused by triple repeat expansions, such as Fragile X Syndrome, Myotonic Dystrophy, and Huntington's Disease. These kits (GeneProber???, Prober??? Gene Detection Kits, GScan??? Gene Detection Kits) utilize agarose, polyacrylamide gel-based systems, and chemiluminescent Southern blot methods.
Disease-Specific Genotyping Kits: The company also supplies research kits for genotyping mutations related to conditions like Sickle Cell Disease and Cystic Fibrosis, as well as kits for SRY/XY determination.
Full-Service Molecular Biology Services
In addition to products, Gene Link offers full-service contract research and production capabilities:
DNA Sequencing: Utilizing ABI capillary technology, they offer various sequencing services, including CloneID for single-run clone identification, DSSeq for publication-quality double-stranded confirmatory sequencing of plasmid DNA or PCR products, and Bac/Pac/P1Seq for terminal end sequencing of large clones.
Custom Gene Construction: This comprehensive service involves synthesizing all necessary oligonucleotides, ligating them into a specified plasmid, transforming the host, and providing the sequenced, quality-controlled clean plasmid and bacterial culture.
Genotyping Services: Full-service genotyping is available to assist researchers with their projects.
Gene Link supports all its products and services with a dedicated technical support team, offering assistance in experimental design and troubleshooting to foster customer loyalty and ensure successful research outcomes.
Please note: This information is generated by AI. For legal use, verify with company sources.
