2. Core Diagnostic Technologies

Sebia's core business revolves around two primary analytical methodologies used to separate and quantify proteins in biological fluids (such as serum, urine, and whole blood):

Capillary Electrophoresis (CE)

Sebia is the global pioneer in automated multi-capillary systems. This technology works by migrating charged molecules through ultra-narrow capillary tubes filled with an electrolyte buffer under an intense electric field. Because molecules migrate at distinct speeds based on their specific mass-to-charge ratios, they separate with extreme precision. * Direct Detection: Proteins are monitored directly via optical sensors at precise wavelengths (eliminating the old requirements for chemical staining or densitometer scanning). * High Throughput & Automation: Multiple capillaries run concurrently to handle heavy sample volumes with total walk-away automation—taking primary sample tubes directly from a rack and delivering completed electronic profiles.

Gel Electrophoresis

For traditional or low-throughput laboratory setups, as well as specific esoteric diagnostic workflows, Sebia offers advanced agarose gel electrophoresis solutions. These systems automate the migration, staining, destaining, and scanning phases of gel testing onto unified instrumentation blocks, minimizing manual human error.

3. Targeted Pathologies & Clinical Menus

Sebia's testing menu targets vital physiological pathways, offering key diagnostic biomarkers for several major disease states:

Oncology (Multiple Myeloma)

Sebia is a fundamental player in the screening and disease management of plasma cell dyscrasias, most notably Multiple Myeloma. * Serum/Urine Protein Electrophoresis (SPEP/UPEP): Used to detect abnormal monoclonal proteins (M-proteins or M-spikes) produced by malignant plasma cells. * Immunofixation & Immunotyping: Advanced typing methods that utilize specific antisera to explicitly identify the heavy chain (IgG, IgA, IgM) and light chain (Kappa, Lambda) composition of an anomalous immunoglobulin. * Free Light Chain (FLC) Assays: The next-generation free light chain assay engineered to measure trace amounts of unbound kappa and lambda chains in serum, critical for monitoring non-secretory or light-chain-only myelomas.

Metabolic Disorders (Diabetes)

• HbA1c Testing: Hemoglobin A1c (glycated hemoglobin) remains the cornerstone for diagnosing and long-term monitoring of Diabetes Mellitus. Sebia's capillary technology separates HbA1c cleanly from normal adult hemoglobins, genetic variants, and chemically modified derivatives (such as carbamylated hemoglobin), providing highly specific results free from common analytical interferences.

Hemoglobinopathies

• Hemoglobin Disorders Screening: Sebia provides gold-standard technology for analyzing qualitative and quantitative hemoglobin abnormalities, such as Sickle Cell Disease and various forms of Thalassemia. This includes specialized testing workflows configured specifically for both adult confirmation and high-throughput newborn screening.

Esoteric & Rare Diseases

• Chronic Alcohol Abuse: Quantification of Carbohydrate Deficient Transferrin (CDT), a highly specific bio-indicator used to monitor chronic alcohol consumption and compliance in addiction treatment programs.
• Alpha-1 Antitrypsin Deficiency: Phenotyping systems utilizing gel electrophoresis to screen for genetic variants causing liver and lung diseases.
• Central Nervous System Inflammatory Diseases: High-resolution oligoclonal banding detection within cerebrospinal fluid (CSF) to aid in the clinical diagnosis of neuro-inflammatory disorders like Multiple Sclerosis.

4. Product Portfolio & Instrumentation

Sebia offers scalable physical instrumentation designed to match the specific volume and throughput requirements of clinical laboratories, ranging from local community health clinics to mega-volume reference networks.

Automated Capillary Systems

• CAPILLARYS 3 TERA & TERA MC: The flagship high-throughput workstation series. Utilizing a 12-capillary simultaneous configuration, the standard TERA handles massive sample loads seamlessly. The "MC" (Multi-Capillary) configuration allows laboratories to link 1 to 3 separate TERA units to an automated tube loader (528 sample positions), creating a unified automated workcell for ultra-high-volume requirements.
• CAPILLARYS 3 OCTA: An 8-capillary system built on the exact same structural platform as the TERA series. It offers complete multi-technique processing capabilities and accommodates up to 120 samples concurrently, making it ideal for medium-to-large institutions looking for premium data resolution.
• CAPILLARYS 3 DBS: A specialized automation system optimized for newborn screening programs. It handles automated sample parsing directly from dried blood spots on filter paper (Guthrie cards), managing microplate dilutions, incubation, and processing across 12 capillaries without requiring human interaction.
• MINICAP FLEX-PIERCING: A compact, benchtop capillary electrophoresis system equipped with cap-piercing technology to process whole blood tubes directly. It provides smaller laboratories with access to the same clinical analytical performance found in Sebia's high-capacity machines.

Gel Electrophoresis Systems

• HYDRASYS 2 SCAN FOCUSING: A complete, all-in-one analyzer for agarose gel electrophoresis. This system accommodates the entire testing process including sample application, migration, incubation, staining, destaining, and integrated densitometry scanning on a single instruments footprint.

5. Software & Laboratory Workflow Solutions

To complement its analytical hardware, Sebia delivers integrated middleware, digital ecosystems, and operational services designed to maximize laboratory efficiency and traceability:

• PHORESIS Software: The proprietary core application packaged with all Sebia instrumentation. PHORESIS acts as the central interface for results interpretation, curve verification, and data management. It enables pathologists to easily compare present results side-by-side with historical patient records, network multiple instruments together, and securely interface with Laboratory Information Systems (LIS).
• Sebia Lean Service & Workflow Consultancies: Specialized operational audits and modular integration solutions provided by Sebia experts. They focus on helping laboratories minimize specimen turnaround times (TAT), optimize chemical reagent storage strategies via RFID tracking, and implement seamless automated tracking from sample collection to final diagnostic reporting.
• Sebia Academy: An educational portal and clinical training ecosystem provided to laboratory managers, medical technicians, and pathologists to ensure up-to-date knowledge on clinical guidelines, troubleshooting, and interpretation of complex electrophoretic patterns.